The Lathrop Family Collection contains materials pertaining to George and Rose Lathrop including correspondence, manuscripts, writings, newspaper clippings, ephemera and photographs. The majority of the collection is correspondence and there are letters written by Rose and George. Additionally, there are a few letters written by Rose after she founded the religious order, Servants of Relief for Incurable Cancer and was known as Mother Mary Alphonsa. Materials date from 1870 to 1910.

This collection consists of small manuscript collections many of which are singular items. It is believed that most were donated to the college at various points of time. Items in the collection are arranged in alphabetical order. There is one box of oversize materials.